Do we know the place of systemic corticosteroids in infectious diseases?
نویسندگان
چکیده
Methods and results We have studied the Cochrane systematic reviews addressing the systemic use of corticosteroids in: • acute bacterial meningitis (to examine the effect versus placebo on mortality, hearing loss and neurological sequelae in participants of all ages); 24 randomized controlled trials (RCTs) enrolling 4041 patients; • tuberculous meningitis (to examine the effect on death or disabling residual neurological deficit); 7 RCTs involving 1140 people; • infectious mononucleosis (to assess efficacy and safety of steroids for symptom control); 4 trials that compared the effectiveness of a steroid for short-term symptom control to a placebo and 3 other trials that used a combination of steroid and an antiviral drug, involving 362 participants; • acute sinusitis (to assess the effectiveness of systemic corticosteroids in relieving symptoms); 4 RCTs with a total of 1008 adult participants; • acute pharyngitis (to assess the clinical benefit and safety of corticosteroids for symptoms of sore throat in adults and children) 8 trials involving 743 participants (369 children and 374 adults); • acute pneumonia (to assess efficacy and safety of corticosteroids), 6 studies including 437 participants; • croup in children (to determine the effect of glucocorticoids), 38 studies were included, enrolling 4299 patients; • acute viral bronchiolitis in children (to evaluate the efficacy and safety of systemic and inhaled glucocorticoids), 17 trials with 2596 participants; • severe sepsis and septic shock (to examine the effects of corticosteroids on death at one month in sepsis), 20 studies involving 2384 patients; • tuberculous pleural effusion (to evaluate the effects of adding corticosteroids to drug regimens), 6 trials with 633 participants.
منابع مشابه
Corticosteroids in Infectious Diseases
Accumulated data based on experiences with curtico,teroids in the management uf infectious diseases, have proved that they are very dfective and ,afe drugs provided that are administered properly. The Corticosteroids arc administered mainly bec,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged t...
متن کاملGuidelines for the use of systemic drugs in the treatment of skin diseases
Systemic drugs are used in the treatment of several skin diseases. In order to obtain best therapeutic results and prevent side effects, the patients should be carefully screened before and thoroughly evaluated during treatment. In this article guidelines for selection and follow up of patients receiving systemic drugs for their skin diseases are presented. These drugs include azathioprine, ant...
متن کاملمقایسه اثر کورتیکوستروئید سیستمیک و موضعی بر علائم بالینی و آزمایشگاهی مبتلایان به رینیت آلرژیک سالانه
Background: Corticosteroids are used for the management of allergic rhinitis. We compared the efficacy of systemic and local corticosteroid in symptom relief and serum IgE levels in patients with perennial allergic rhinitis. Methods: A randomized experimental study design, (clinical trial) was used. 86 patients with a history of perennial allergic rhinitis were selected and randomly divided i...
متن کاملCorticotherapy in Eye Diseases and Its Complications
Corticosteroids are being rn;;ed in different ophthalmic disorder as anti-inflamatory agent. A.C.T.H. stimulated the supra renal glands and causes an increase steroid concentration of the blood. Corticosteroids can be used as antiinflamatory agent locally ar.d systemically. The new corticom,teroids like prednison, dexxametason and prednisolon are more effective ( 5 to 10 times) than the o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2013